Research conducted on degenerative diseases of the “third age”, have seen in recent years the studygroup of Palermo investigate and propose solutions ranging from the development of guidelines forthe design of “Nursing Homes”, the final design of residential architectures, the recovery and reuse ofexisting buildings and the design of the domestic space dedicated and protected for disadvantagedgroups. For nearly two years this area of research is supported by a new area of investigation relatedto the always “social minority”. The request was made by the Students of Palermo, who feel the needsof autistic involved the research team to confront with this particular disease. From time architectsdevelop proposals for environmental and functional research of the architectural space in support ofthis behavioral disorder, complex and destabilizing for autistic and those who are indirectly involved,since it is manifested by the original and unique events, which change from individual to individual.The research team of Palermo has traced the guidelines useful for building design and environmental,to give answers to the many questions that the spatial and functional Autism presents. The teamproposed intervention programs that aim to recover the existing abandoned building with proposalsto adapt according to the needs that this condition requires. Another aspect investigated in theresearch was the design of possible architectural solutions and communication aimed at thedissemination and information about Autism, because the disease is often not known or understoodcorrectly, precisely because of the little knowledge that the society has with it.In this short paper we will be presented two projects, the result of research for Thesis. The first is a“Temporary System”, whose aim is to publicize the knowledge of this disease, little known to thepublic opinion and even less to designers and architects; the Thesis proposes a system of Temporarypavilions, three of which directed to autistic children to facilitate the orientation and conduct oftherapeutic activities, one dedicated to the dissemination and information and the latest dedicated toparents. The second relating to the reuse of unused hospitals present in Palermo and converted “DayCentre” for children and adolescents with “autism spectrum disorders”, with the aim to realizeconstruction specialized for the treatment of this condition.