The architects Richard Neutra and Charles Moore can be considered the pioneers of the relationship architecture-neuroscience. The complexity of Neutra’s method: the bio-realism, is expressed in his building such as in his essays. Also Charles Moore based his projects on the sense of body and on memory, involving client’s physical and mental senses, and expressed his thought through his essays. Neutra and Moore worked mainly in the same place, the California State, but with a different approach: more scientific the former, interested in a Baroque revival of senses the latter. Starting with a close examination of their theoretical contribution, this paper will aim at a definition of their legacy in the contemporary debate on this matter